Abstract
Water soluble and biocompatible iron oxide nanoparticles coated with poly(aspartic acid) (PAsp), poly(asparagines) (PAsn), poly(2-hydroxy-ethyl l-aspartamide) (PHEA), and poly-α,β-(N-2-dimethylaminoethyl l-aspartamide) (PDMAEA) were prepared by hydrophobic interaction between hydrophobic iron oxide nanoparticles and each amphiphilic poly(amino acid)s graft polymer. The octadecyl side chain grafted poly(succinimide)(PSI-g-C18), used as a precursor polymer, was easily aminolyzed with nucleophilic compounds to form various poly(amino acid)s graft polymer (PAsp-g-C18, PAsn-g-C18, PHEA-g-C18, PDMAEA-g-C18,) and simultaneously stabilize the dispersion of iron oxide nanoparticles in aqueous solution. The diameters of the poly(amino acid)s coated iron oxide nanoparticles (PAIONs) were smaller than 30nm in aqueous solution, extremely stable in aqueous solutions with a wide range of pH and salt concentrations. Further, all the PAIONs showed excellent MR signal intensities (high r2 values) and the cellular uptake property of the PAIONs was also evaluated.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
