Abstract
A diorganotin(IV) complex formulated as [(Me)2Sn(L)] (1) (H2L = 2,6-diacetylpyridine bis(N4-cyclohexylthiosemicarbazone) has been synthesized and structurally characterized by elemental analysis, IR, UV, and NMR spectroscopy, and single-crystal X-ray diffraction. Complex 1 contains mononuclear neutral molecules composed of one N3S2 pentadentate anionic thiosemicarbazone ligand and one (Me)2Sn(IV) group with a seven-coordinated tin ion. In vitro biological studies have indicated that complex 1 exhibited enhanced cytotoxicity compared to the thiosemicarbazone alone against human hepatocellular carcinoma HepG2 cells and could slightly distinguish HepG2 cells from normal hepatocyte QSG7701 cells.
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