Abstract
A dinuclear ruthenium(II) complex Ruazo was designed and synthesized, in which oxidative cyclization of the azo and o-amino group was employed for the detection of hypochlorous acid (HClO) in aqueous solution. The non-emissive Ruazo formed highly luminescent triazole-ruthenium(II) complex in presence of HClO and successfully imaged HClO in living cell and living mouse.
Highlights
A dinuclear ruthenium(II) complex Ruazo was designed and synthesized, in which oxidative cyclization of the azo and o-amino group was employed for the detection of hypochlorous acid (HClO) in aqueous solution
It is reported that HClO may cause lysosomal rupture[9], mitochondrial permeabilization[10], proteinase inactivation[11,12] and cell death through calcium dependent calpain[10]
As far as we know, there is no luminescence probe based on an azo-o-amino ruthenium(II) complex reported for the detection of HClO in aqueous solution[32,33,34,35,36,37,38,39,40,41,42,43]
Summary
A dinuclear ruthenium(II) complex Ruazo was designed and synthesized, in which oxidative cyclization of the azo and o-amino group was employed for the detection of hypochlorous acid (HClO) in aqueous solution. The almost non-emissive dinuclear ruthenium(II) complex Ruazo formed highly luminescent product triazole-ruthenium(II) complex Rutazo in presence of hypochlorous acid with an oxidative cyclization of the azo and amino group in the dinuclear ruthenium(II) complex, which can detect HClO without interference of Cu2+ in the PBS buffer (Figure S2, S4), and showed highly sensitive and selective luminescent responses towards HClO without interferences of other ROS/RNS. Based on these features, we use this probe to investigate its luminescence response behavior towards exogenous HClO in living cells and living mouse successfully
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