Abstract
The process of forming amyloid fibrils from misfolded proteins occurs through a nucleation-dependent polymerization reaction, which has also been studied in the context of neurodegenerative diseases, including Parkinson's disease (PD). PD severity is strongly correlated with the accumulation of intraneuronal α-synuclein aggregates, making pathological α-synuclein isoforms promising biomarkers for PD. α-synuclein aggregates can be detected using seed amplification assays (SAAs), however, these assays are not quantitative and suffer from a lack of reproducibility.
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