Abstract
This article discusses the mathematical pharmacokinetic models with reference to one open compartment model in detail. Four types of models, IV, bolus, extravascular 1st and 0 order, have been studied. Mathematical approaches to predict the pharmacokinetic parameters, including elimination half-life, rate constant and drug clearance, have been included. This article focuses on the significance of one open compartment model to study the distribution and elimination of drugs in the body beforehand, to determine whether the drugs under study should proceed to clinical trials or not. Thus, the prediction of the pharmacokinetics of the drug at an earlier stage with the help of this mathematical model saves time and cost during drug and discovery and drug development.
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