A Decision Support System For Detecting Stage In Hodgkin Lymphoma Patients Using Artificial Neural Network and Optimization Algorithms

Abstract

Hodgkin-type lymphoma is a disease with unique histological, immunophenotypic, and clinical features. This disease occurs in nearly 30% of all lymphomas. Its treatable is high. However, the treatment plan is specified after the stage and risk status are determined. For this reason, it is an important process for doctors to decide on the stage of the disease correctly. Some of the data used for this decision are the patient's history, detailed physical examination, laboratory findings, imaging methods and bone marrow biopsy results. Hybrid FDG-PET is the other method used in the medical world. This method is used in diagnosis, evaluation of response given to treatment, staging and restaging process. However, it is radiation-based. Therefore it has the possibility of producing undesirable results in the future. In this study, an artificial intelligence-based computer-assisted decision support system is done to reduce the number of used medical methods and radiation exposure. Data were obtained from the NCBI-GEO dataset. The evaluation of these data, which contains missing values, is handled in two ways. Firstly, samples with missing values in the initial evaluation are deleted from the dataset. Then, these data are trained with “trainlm” function in artificial neural network architecture. However, reducing the error value of the estimates is important. For this, the artificial neural network architecture is retrained with the artificial bee colony algorithm, particle swarm optimization algorithm and invasive weed algorithm, respectively. Secondly, the same operations are performed again on the dataset containing missing values. As a result of the training, the maximum performance was obtained for invasive weed and particle swarm optimization algorithms with 1,45547E+14 and 1,23103E+14 average error rates, respectively.