Abstract
Background. Chyawanprash awaleha (Cp) is an Ayurvedic rasayana formulation and is used as a genoprotective agent.Objective. The present cytogenetic study has been done to investigate the efficacy of Cp against betel quid chewers suffering from oral precancerous lesions through satellite association (SA) assay.Materials and Methods. The frequency of SA was analyzed in 21 betel quid chewing oral precancerous lesions patients and then they were divided into 2 groups. Group 1 consisted of 15 patients, advised to quit betel quid chewing and fed with 20 gms of Cp, twice a day for three months. Group 2 consisted of 6 patients, who refused Cp feed but accepted to quit betel quid chewing. At the end of three months, both groups were assessed cytogenetically.Results. The frequency of SA was statistically significant in both groups, but an elevated mean difference was observed more in Group 1 than in Group 2.Conclusion. The study indicates that betel quid cessation reduces the effect of DNA damage in oral precancerous lesions. But the increased mean difference in SA in Group 1 compared to Group 2 clearly indicates that Cp can further minimize the genotoxic effect caused by mutagenic agents present in betel quid.
Highlights
In India, annually 130,000 people die of tobacco related oral cancer taking it to a third position as the most common cancer [1]
At the end of three months even though both the groups had completely quit betel quid chewing, the problem of acute burning sensation in the mouth and the clinical presentations of the oral precancerous lesions in Group 1 patients had almost disappeared than Group 2 patients
The frequency of satellite association (SA) was analyzed from Group 1 patients before quitting betel quid and the same patients SA was analyzed after three months of quitting betel quid and taking Chyawanprash awaleha (Cp) feed
Summary
In India, annually 130,000 people die of tobacco related oral cancer taking it to a third position as the most common cancer [1]. Identifying the patients of their genetic damage through cytogenetic studies and treating them with Chyawanprash Awaleha, an antioxidant, seemed to be a promising strategy and an attractive alternative that reduces toxic effects of tobacco. Chyawanprash Awaleha known for its anti-inflammatory, antioxidant, and anticarcinogenic properties has been used in India as a health food continuously for the past 4000 years [3]. It is almost a house old product in India and is taken as a health food by the young and old people. The frequency of SA was analyzed in 21 betel quid chewing oral precancerous lesions patients and they were divided into 2 groups. The study indicates that betel quid cessation reduces the effect of DNA damage in oral precancerous lesions. The increased mean difference in SA in Group 1 compared to Group 2 clearly indicates that Cp can further minimize the genotoxic effect caused by mutagenic agents present in betel quid
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