Abstract
In a direct preparation from a male breast carcinoma two populations of cells were present, one hypodiploid (range 25–34) and the other hypertriploid (range 56–84). Twenty-two marker chromosomes were recognized. One of these, dic(5;11)(p14;q23) was present in one or two coples in every cell and has not been reported in any other case of breast cancer. There was a consistent monosomy of chromosome 7 and, in the hypertriploid cells, a gain of one to three copies of chromosome 3. The breakpoint 11q23 in a rare, folate-sensitive fragile site but was not expressed in peripheral blood cell lymphocytes from the patient.
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