A Cyclical Magneto-Responsive Massage Dressing for Wound Healing.

Abstract

Tissue development is mediated by a combination of mechanical and biological signals. Currently, there are many reports on biological signals regulating repair. However, insufficient attention is paid to the process of mechanical regulation, especially the active mechanical regulation in vivo, which has not been realized. Herein, a novel dynamically regulated repair system for both in vitro and in vivo applications is developed, which utilizes magnetic nanoparticles as non-contact actuators to activate hydrogels. The magnetic hydrogel can be periodically activated and deformed to different amplitudes by a dynamic magnetic system. An in vitro skin model is used to explore the impact of different dynamic stimuli on cellular mechano-transduction signal activation and cell differentiation. Specifically, the effect of mechanical stimulation on the phenotypictransition of fibroblasts to myofibroblasts is investigated. Furthermore,invivoresults verify that dynamic massage can simulate and enhancethetractioneffect in skin defects, thereby accelerating the wound healingprocessbypromoting re-epithelialization and mediating dermal contraction.