Abstract
Optical systems applied for tissue analysis are primarily based on single spectroscopic techniques. This paper however presents a multispectral backscattering sensor designed for in vivo application by a specially formed probe tip which allows side by side monitoring of ultraviolet, visible, near-infrared and fluorescence spectra. The practical applicability of the measurement system was demonstrated in vitro (muscle and adipose tissue) and in vivo in an animal model (mouse). By comparing associated measuring changes in biochemical, physical-morphological and colorimetric values this procedure allows a differentiation between healthy, marginal and malignant tissue.
Highlights
Cancer ranks number two among the causes of death annually; more than 14 million new diagnosed cases occurred in 2012 [1]
The setup was composed of a customized multispectral needle probe and an integrated set of different light sources as well as spectrometers all of which are described in detail
The measured data were processed by a virtual photometric setup and combined and clustered into groups
Summary
Cancer ranks number two among the causes of death annually; more than 14 million new diagnosed cases occurred in 2012 [1]. Estimations forecast that over 22.2 million cases will occur in 2030 [2]. Different biopsy techniques with subsequent evaluation by a pathologist based on microscopy images in a laboratory are the gold standard for diagnosis of tissue alterations [3, 4]. Each histopathological examination is usually carried out by hand—not automatically, and generally very cost intensive. In such cases, optical spectroscopy, especially for prevention and early diagnosis, offers benefits as a minimally invasive preselection and supporting tool implemented during the biopsy procedure
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