A CT-Based Radiomics Nomogram for Predicting Early Recurrence in Patients with High-Grade Serous Ovarian Cancer

Abstract

Purpose: To develop and validate a radiomics nomogram for predicting early recurrence in high-grade serous ovarian cancer (HGSOC) patients. Materials and Methods: From May 2008 to December 2019, 256 eligible HGSOC patients were enrolled and divided into training (n=179) and test cohorts (n=77) in a 7:3 ratio. A radiomics signature (Radscore) was selected by using recursive feature elimination based on support vector machine (SVM-RFE) and building a radiomics model for recurrence prediction. Independent clinical risk factors were generated by uni variable and multivariable Cox regression analyses. A combined model was developed based on the Radscore and independent clinical risk factors and presented as a radiomics nomogram. Its performance was assessed by the AUC, Kaplan-Meier survival analysis and Decision curve analysis. Results: Seven radiomics features were selected. The radiomics model yielded AUCs of 0.715 (95% CI: 0.640, 0.790) and 0.717 (95% CI: 0.600, 0.834) in the training and test cohorts. The clinical model (FIGO stage and residual disease) yielded AUCs of 0.632 and 0.691 in the training and test cohorts. The combined model demonstrated AUCs of 0.749 (95% CI: 0.678, 0.821) and 0.769 (95% CI: 0.662, 0.877) in the training and test cohorts. In the combined model , PFS was significantly shorter in the high-risk group than in the low-risk group (P<0.0001). Conclusions: The radiomics nomogram performed well for early individualized recurrence prediction in patients with HGSOC and also can be used to differentiate high-risk patients from low-risk patients. Funding: This study was supported by Sichuan Science and Technology (ProgramNo.2020YFS0050), the Clinical research item in West China Second University Hospital, Sichuan University (KL007) Declaration of Interest: None to declare. Ethical Approval: This retrospective study was approved by the Institutional Review Board of West China Second University Hospital (No. 2020173)