Abstract
Objective: To investigate the prevalence of thyroid diseases in patients with oral lichen planus (OLP) and to explore the correlation between the two diseases.Methods: A cross-sectional study was conducted to investigate the history of thyroid disease in 585 patients with oral lichen planus diagnosed in the Department of Oral Mucosal Diseases of the Ninth People's Hospital, Shanghai Jiaotong University, School of Medicine from June 2017 to April 2018 and in 10,441 normal people in an epidemiological survey conducted by endocrinology department of Ninth People's Hospitalin eastern China from 2014 to 2015. Personal medical history of thyroid disease was obtained through questionnaire and thyroid function was also tested.Results: Of the 585 patients with OLP, 190 (32.48%) had thyroid disease (excluding coexistence of multiple thyroid diseases), 62 (32.6%) had thyroid nodules, and 71 (37.4%) had Hashimoto's thyroiditis. Hyperthyroidism was diagnosed in six patients (3.2%), hypothyroidism in seven patients (3.7%), and thyroid cancer in 11 patients (5.8%). The prevalence of Hashimoto's thyroiditis was significantly higher in patients with oral lichen planus than in the general population. The probability of thyroid disease was significantly higher in women with OLP than in men with OLP (P < 0.001).Conclusion: OLP is associated with a high probability of developing thyroid disease, especially Hashimoto's thyroiditis. In the management of OLP patients, especially in female patients, thyroid disease must be screened.
Highlights
Oral Lichen Planus (OLP) is a chronic inflammatory oral mucosal disease, which is common in middle-aged women [1]
In 2016, a study was conducted by Chinese Society of Endocrinology, revealing that more than 40% of the population suffered from Thyroid diseases (TD) [8]
The prevalence of Hashimoto’s thyroiditis (HT) in OLP patients was significantly higher than that in control group, but there was no difference among male (Table 5)
Summary
Oral Lichen Planus (OLP) is a chronic inflammatory oral mucosal disease, which is common in middle-aged women [1]. Several studies indicated that OLP is closely related to some systemic diseases, such as diabetes mellitus (DM), hepatitis C and thyroid diseases [3, 4]. Among these diseases, some scholars have shown that the OLP and Thyroid Disease, China immune system may play a critical role in the appearance of OLP in patients with type I DM [5]. Several studies in other populations have investigated the possible relationship between thyroid diseases and OLP [12,13,14]. One literature from China reported the possible relationship between OLP and TD in northern Chinese population, and this study included
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