Abstract
Lichen planus (LP) is a common papulosquamous skin disease with a prevalence 1-2% globally and 0.1 - 1.5% in Indian studies with many morphological presentations. LP is strongly associated with chronic HCV infection (3.1- 18.3% in different studies), while the association with other viral infections (Hepatitis B and HIV) is not that strong. There are only a few studies in Indian patients and the association reported is not uniform. Further studies will help to consolidate the association.1) To study the epidemiological and clinico- histopathological pattern in LP.2) To determine the serology and assess the possible association with HCV, HBsAg and HIV.140 patients of LP after histopathological confirmation were tested for detection of HCV antibodies, Hbs antigen and HIV antibodies by HCV-TRIDOT, HEPACARD and HIV –TRIDOT respectively. Statistical analysis was performed by SPSS software 20.0.Most common age group involved was 21-30 years. 75.6% of the patients presented with in 6 months of onset. Extremities and trunk were commonly involved. The most common clinical variants are classical LP(35%) and hypertrophic LP(31%). Mucosal involvement alone was observed in 9.3% patients . HBs Ag was positive in 4 cases , Anti HCV antibodies were positive in 3 cases and HIV was reactive in 3 cases.There is no significant relationship between LP and Hepatitis B, C and HIV virus. It may be suggested that viral serology (HBV, HCV, HIV) may not be necessary in routine screening for LP.
Highlights
IntroductionLichen planus (LP) is a common papulosquamous skin disease with a prevalence of 1-2% globally and 0.1% to 1.5% in Indian studies. 1 The disease was mostly reported in middle-aged patients 30-60 years of ageand is less common in extremes of age. 1 Few studies show female preponderance. 2,3 LP most commonly involves the flexor surfaces of extremities with pruritic, purple, polygonal, planar, papules, plaques
Lichen planus (LP) is a common papulosquamous skin disease with a prevalence 1-2% globally and 0.1 - 1.5% in Indian studies with many morphological presentations
More significant association was seen in Oral lichen planus. 7–12 Few studies have found no association between HCV infection and lichenplanus. 13–18 Though there were several reports showing a higher prevalence of HBV with LP, a possible association between HBV infection and LP remains unclear. 19,20 Regarding association of HIV and LP, very few reports were there from India and the relation was not consistent
Summary
Lichen planus (LP) is a common papulosquamous skin disease with a prevalence of 1-2% globally and 0.1% to 1.5% in Indian studies. 1 The disease was mostly reported in middle-aged patients 30-60 years of ageand is less common in extremes of age. 1 Few studies show female preponderance. 2,3 LP most commonly involves the flexor surfaces of extremities with pruritic, purple, polygonal, planar, papules, plaques. Lichen planus (LP) is a common papulosquamous skin disease with a prevalence of 1-2% globally and 0.1% to 1.5% in Indian studies. Strong association has been reported with HCV infection, while. The association of HCV infection and lichen planus varied from the different studies. Positive association was seen in 3.1% to as high as 18.3%. More significant association was seen in Oral lichen planus. 7–12 Few studies have found no association between HCV infection and lichenplanus. 13–18 Though there were several reports showing a higher prevalence of HBV with LP, a possible association between HBV infection and LP remains unclear. 19,20 Regarding association of HIV and LP, very few reports were there from India and the relation was not consistent. 21 We conducted a prospective study to assess the association of HCV, HBV, HIV infections with LP. Sneha et al / IP Indian Journal of Clinical and Experimental Dermatology 2020;6(1):[57–61]
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