Abstract
Abstract The Ellis (1968) formulae for a unit of biologically effective dose are derived by applying doubtful assumptions to questionable data. Clinical and experimental evidence suggests that these formulae are not true for tumours in general, not true for all normal tissues and only approximately true for skin. A later version of the formula for normal tissues proposed by Winston et al. (1969) suffers from an additional disadvantage, in that it contains a quantity (NSD) which varies from one centre to another, so that identical treatments would be considered by different centres to be equivalent to different ret doses. An international unit of biological effect based on the concept of an equivalent single dose, as suggested by Ellis 1968), would be useful, but for any given treatment regime the equivalent single dose is liable to vary from tissue to tissue and therefore needs to be defined in terms of one specific tissue. The data of Fowler (1965) applied to skin reaction are probably the most reliable ...
Published Version
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