Abstract
The cellular surviving fraction is used as a biological measure of radiation effect to evaluate and compare results of variously fractionated treatment schemes. It is derived from a kinetic model simulating the changing cell population in irradiated tissues and tumors. Equivalent single doses and response rates (probits) can also be computed on this basis. From these factors, the probability of obtaining a given “response” (cure of a tumor or a specified reaction in normal tissue) can be estimated. An interactive program (RADLOG) has been developed for computing the cellular surviving fraction, equivalent single dose, probit and probability of response, from clinical dose-time-volume data. The effects of additional or alternative procedures can be explored. Also, the computer can be instructed to find the dose required to achieve a particular biological effect, specified in terms of a given degree of cellular depletion (log-surviving-fraction) or a preselected response rate. Various options can be used to take decisions on the efficiency and safety of proposed treatment schedules and to make corrective adjustments when necessary.
Published Version
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