Abstract
Background and Objective: The effect of the hormonal changes associated with menopause on the serum lipid levels may play an important role in most cardiac related disorders associated with menopause. The aim of the present study was to investigate the correlation between the lipid profile and estrogen level in premenopausal and postmenopausal women. Materials and Methods: The premenopausal females of 25 - 35 yrs in their follicular phase of menstrual cycle were selected and two groups of post menopausal women, 10 yrs of menopause were selected. About 6ml of blood sample was drawn for the estimation of estrogen and 4ml of blood for the estimation of lipid profile. The data were expressed as Mean ± SD. The correlation of estrogen level with lipid profile was done using correlation test and P value less than 0.05 was considered significant. Results: HDL cholesterol was found to be significantly declined in postmenopausal (p 0.1) in all the three groups. Conclusion: Estrogen may be the protective factor that is causing lesser incidence of these diseases in premenopausal women.
Highlights
Menopause is a physiological phenomenon wherein the permanent cessation of menstruation takes place
After Rudolph Virchow stressed that lipid was an important constituent of atheromatous lesions[1], studies were done in this matter and it is clear that elevated levels of certain types of lipoproteins substantially increase the risk of atherogenesis in individual patients
Under all aseptic precautions 6ml of blood sample was drawn from antecubital vein and was collected in two clean dry bottles. 2ml blood sample was collected in one bottle for Estrogen estimation and 4ml plain blood sample was collected in other bottle for lipid profile
Summary
Menopause is a physiological phenomenon wherein the permanent cessation of menstruation takes place. The ovarian stroma continues to secrete androgen and a proportion of androgen from ovary and adrenal cortex is converted peripherally into oestrogen, so that not all postmenopausal women are oestrogen deficient and develop long term effects of menopause which include increased bone loss leading to osteoporosis and atherosclerosis. The aim of the present study was to investigate the correlation between the lipid profile and estrogen level in premenopausal and postmenopausal women. The correlation of estrogen level with lipid profile was done using correlation test and P value less than 0.05 was considered significant. The correlation of estrogen level with other parameters of lipid profile didn’t exhibited any significant correlation (p>0.1) in all the three groups.
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