A CORRELATIVE STUDY OF ENDOMETRIAL GLYCOGEN CONTENT AND OTHER CONTRIBUTORY FACTORS ON FEMALE INFERTILITY

Girish C J,Manjunath M L,Nagarajappa A H,Naveen S Kotur

doi:10.7439/ijbar.v3i1.225

Abstract

Background and Objective: Endometrial glycogen is one of the most important factors for development of the blastocyst in the early stages of gestation which is reconverted into a simple monosaccharide like glucose at the time of implantation. Hence in the present study, the role of glycogen content in the endometrium and other factors like age, duration of infertility pattern of menstruation and other clinical features in causing infertility was studied.Materials and Methods: This study was carried out in the Department of Pathology, Bangalore Medical College after the ethical clearance from the institutional ethics committee. The study included 90 cases with complaints of infertility (primary / secondary). The endometrial tissue was fixed; processed, sectioned and performed Periodic Acid Schiff (PAS) stain for detecting the amount of glycogen in endometrium. The present prospective study was a descriptive study and the values are mentioned in percentages. Result: We observed that, the majority of primary infertility patients were in the age group of 21-25 years and that of secondary were in 26-30 years. Most of the patients 55(74.3%) in primary & 12(75%) had regular cycles. The duration of primary infertility group was 2-3 years and that of secondary infertility group was 4-5 years. The glycogen content in the endometrium was grossly reduced in patients with Luteal Phase Defects. Conclusion: We found that the glycogen content of endometrium was very much deficient in late secretory phase might be one of the major causes for female sterility.

Highlights

Infertility is a global public health concern, partly due to its complexity and difficulty in preventing, diagnosing and treating it
Result: We observed that, the majority of primary infertility patients were in the age group of [21-25] years and that of secondary were in [26-30] years
Result: The present study reports the role of glycogen content in the endometrium and other factors like age, duration of infertility,pattern of menstruation and other clinical features in causing infertility was recorded. 3.1 Age incidence: The youngest patient seen was 18 years old and eldest was 38 years in primary infertility cases with an average age of 24.2 ± 2.0 years

Summary

Introduction

Infertility is a global public health concern, partly due to its complexity and difficulty in preventing, diagnosing and treating it. The most accepted definition is “a couple is considered clinically infertile only when pregnancy has not occurred after at least 12 months of regular sexual activity without the use of contraceptives”[2]. Infertility is defined as the failure of a couple of reproductive age to conceive after 12 months of regular coitus without contraception[5]. Glycogen makes its appearance in the glandular epithelium shortly before ovulation and increases progressively in quantity during the secretory phase of the endometrium It shifts into the lumina of the glands along with the secretion. There is a slight reduction in the amount of glycogen in the epithelia of the glands at this time These fluctuations are not seen in the basal layer of endometrium. Since there was a scarcity in the literature on the role of glycogen content in the endometrium as a determinant of infertility in females, prompted us to undertake this study to explore the role of glycogen content in the endometrium and other factors like age, duration of infertility pattern of menstruation and other clinical features in causing infertility

Materials and Methods

Result

Findings

Discussion