Abstract
A copper-free palladium-catalyzed cross coupling of vinyl tosylate (2) and terminal acetylenes was investigated, affording a convenient and efficient method for construction of an sp–sp2 carboncarbon bond. The tosylate (2) derived from 1,3-cyclohexanedione was reacted with terminal acetylene under the copper-free conditions at ambient temperature, in the presence of palladium acetate and triphenylphosphine, to provide the conjugated en-yn-one products in excellent overall yields while leaving other functional groups intact. This reaction protocol was extended to coumarin tosylate (12).
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