Abstract
Recent experiments at the level of a single cell have shown that gene expression occurs in abrupt stochastic bursts. Further, in an ensemble of cells, the levels of proteins produced have a bimodal distribution. In a large fraction of cells, the gene expression is either off or has a high value. We propose a stochastic model of gene expression, the essential features of which are stochasticity and cooperative binding of RNA polymerase. The model can reproduce the bimodal behavior seen in experiments.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have