Abstract

(E)-γ-Hydroxy and (E)-γ-keto-α,β-unsaturated sulfoxides have been easily prepared in good chemical yield from simple aldehydes 2 and chiral bis-sulfoxide 4 using a SPAC-type reaction. The onepot procedure is based on a Knoevenagel condensation, subsequent prototropic shift and [2,3] sigmatropic sulfoxide-sulfenate rearrangement.

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