Abstract
Abstract We designed an efficient three step procedure for the synthesis of N4-isobutyryl-2′-O-methylcytidine. This protected nucleoside was then used to prepare a methylphosphonamidite monomer for incorporation into oligonucleotides. Transamination at the C4 position of cytidine using ethylenediamine, which has been reported for the N4-benzoyl cytidine, was not observed with N4-isobutyryl protected 2′-O-methylcytidine.
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