Abstract
High yields of 5'-acyl-deoxyribonucleosides can be obtained by direct acylation of the substrates with carboxylic acid after activation with N,N-bis-(2-oxo-oxazolidin-3-yl) phosphorodiammidic chloride (BOPDC). In the same experimental conditions a chemoselective benzoylation of unprotected deoxyadenosine can be carried out. Nucleotide building blocks have been prepared from the base labile 5 '-protected nucleosides thus obtained.
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