Abstract
A highly efficient synthesis of C3-arylbutenolides by Suzuki-Miyaura coupling is described. We developed a simple protocol to accomplish scaffolds of C3-arylbutenolides which include antifungal agent (−)-incrustoporin and twelve analogues by Pd-catalyzed Suzuki-Miyaura cross coupling reaction between chiral 3-iodobutenolide and various aryl boronic acids under aerobic conditions in good to quantitative yields.
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