Abstract

An optically pure C-6 O-acyl side chain equivalent of zaragozic acid A, (2E, 4S, 6S)-4, 6-dimethyl-2-octenoic acid, which features a 1, 3-syn-dimethyl-substituted carbon chain, has been readily synthesized from (S)-2-methylbutanal using a combination of the Evans aldol reaction and the Ireland deoxygenation method.

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