Abstract
A computational model of dopamine and tyramine interactions in striatal storage vesicles
Highlights
The vesicular monoamine transporter pumps dopamine, norepinephrine, and five-hydroxy tryptamine into synaptic storage vesicles
We developed a computational model for simulating dopamine and tyramine uptake into vesicles and their displacement by various types of compounds
The time to reach steady-state is quicker for more permeable compounds
Summary
The vesicular monoamine transporter pumps dopamine, norepinephrine, and five-hydroxy tryptamine into synaptic storage vesicles. Published: 11 July 2008 BMC Neuroscience 2008, 9(Suppl 1):P109 doi:10.1186/1471-2202-9-S1-P109 A variety of exogenous amines are substrates for this transporter. Amines can be redistributed out of vesicles by compounds that inhibit the VMAT or by substrates for the VMAT.
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