Abstract
An unmatched coronavirus; termed Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has been arisen in the end of 2019 in Wuhan, China resulted in a pandemic COVID-19 disease. In 2021, there were many mutations disseminated all over the world termed variants of concern. One of the critical main challenges is how to diagnose precisely the disease without confusion with another flu and respiratory distress causing viruses. The various clinical, radiological, laboratory, serological and molecular diagnostic approaches were discussed in this article.
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