Abstract

AbstractMetal oxide nanoparticles (NPs) have found a variety of applications in numerous industrial, medical, and environmental fields s, attributable to recent advances in the nanotechnology field. Titanium dioxide nanoparticles (TiO2-NPs) have gained importance as metal oxide NPs due to their potential in various fields, particularly nanomedicine and other biomedicine fields. Several studies have confirmed that NPs produced via the biosynthesis route using natural resources have significant advantages such as fewer toxic contaminants, less subsequent complex chemical synthesis, environmental friendliness, cost-effectiveness, and stability when compared to NPs produced by conventional methods, and its production with controlled shapes and sizes. Therefore, considerable effort is being expended to implement biological synthesis methods with these proven advantages. TiO2-NPs can be made using a variety of biological, chemical, and physical methods. Physicochemical methods are costly, emit high levels of toxic chemicals into the atmosphere, and consume a lot of energy. On the other hand, the biological approach is an environmentally safe, cost-effective, dependable, convenient, and easy way to synthesize TiO2-NPs. In this review, the bio-mediated synthesis, as well as various biomedical applications of TiO2-NPs, were discussed.

Highlights

  • The emerging field of nanotechnology mainly focuses on materials that have a particle size in the range of 1‒100 nm, and these particles are known as nanoparticles (NPs)

  • To the best of our knowledge, we have tried to summarize the different green synthesis research approaches for TiO2-NPS. Their various applications in biomedical and environment have been discussed, which may clear our thoughts in this field and lead us to intrigue toward more sophisticated nanostructures in the coming years

  • The biological methods incorporate the “green synthesis” [40] of metal oxides that can be further divided into (a) photosynthesis and (b) biosynthesis

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Summary

Introduction

The emerging field of nanotechnology mainly focuses on materials that have a particle size in the range of 1‒100 nm, and these particles are known as nanoparticles (NPs). The unique properties of NPs have been summarized in terms of optical, electrical, thermal, photochemical, energy, biomedical science, and catalytic properties [4,5,6]; these can be well channelized in “nano industries” for better and sustainable industrial applications to protect the biological life [7]. In this regard, transition metals have gained a lot of attention due to (i) the incomplete d-orbitals in their atomic electronic configuration and (ii) and their tendency to undergo variable oxidation states. Their various applications in biomedical (i.e. antibacterial, anticancer, antifungal, and antiviral) and environment have been discussed, which may clear our thoughts in this field and lead us to intrigue toward more sophisticated nanostructures in the coming years

Background
Biological methods for TiO2-NP synthesis
19. Cucurbita pepo
Biological applications
Fusarium oxysporum
Antibacterial applications of TiO2-NPs
Toxicity of TiO2-NPs
Antiviral properties of TiO2-NPs
Anticancer activity of TiO2-NPs
Antifungal activity of TiO2-NPs
Antioxidant activity of TiO2-NPs
Theranostics
Toxicological evidence
Drug delivery systems using TiO2-NPs
Stimuli-responsive release systems
PDT of TiO2-NPs
Radiotherapy
Findings
Biosensor applications of TiO2 applications
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