A comprehensive Meta-analysis of association between genetic variants of COL12A1-rs970547 and ACL tear

Abstract

Objective To identify the relationship between COL12A1-rs970547 and anterior cruciate ligament (ACL) tear. Methods We investigated the association between COL12A1-rs970547 and ACL tear using Meta analytic techniques, combining all published data up to March 2018. Results 5 independent samples from 5 research teams contributed data on COL12A1-rs970547 and ACL tear. The total number of cases and controls for this marker was 686 and 890. When all groups were pooled, a statistically significant summary OR was found between ACL tear and COL12A1-rs970547 allele G vs A[OR=1.29, 95% CI (1.05, 1.60) , P=0.02], genotype (AG+GG) vs AA[OR=1.49, 95% CI (1.17, 1.89) , P=0.001], AA vs GA[OR=1.57, 95% CI (1.23, 2.01) , P=0. 0003]. When analyses were restricted to more race homogeneous populations, significant association of allele G vs A[OR=1.76, 95% CI (1.20, 2.57) , P=0.004], genotype (AG+GG) vs AA[OR=2.93, 95% CI (1.58, 5.44) , P=0.0007], genotype AA vs GG[OR=3.92, 95% CI (1.46, 10.47) , P=0.000 7]and AA vs GA[OR=2.83, 95% CI (1.50, 5.34) , P=0.001] with increased ACL tear risk was found in Asian population. Conclusion Our results suggested that COL12A1-rs970547 may have effect on the susceptibility to ACL tear, at least in Asian population. Key words: COL12A1; rs970547; Variation, polymorphism; ACL tear; Meta analysis