Abstract
This study was performed to investigate, the changes of tear film and ocular surface in diabetic patients by assessing the corneal sensitivity test, tear secretion test and comparing the results with those in a normal control group. The present study was carried out in K.M.C. Mangalore in 100 eyes of fifty patients of Type 2 Diabetes Mellitus (Cases) and 100 eyes of fifty healthy individual (Controls) . Corneal sensitivity, Tear film break up time, Rose bengal test and Schirmer test without topical anesthesia (total tear secretion test), and Schirmer test with topical anesthesia (basal tear secretion test) was measured. Results showed that corneal sensitivity was significantly lower (P < 0.001) in the diabetic group than in the control group. Tear film BUT was significantly shorter (P < 0.001) in the diabetic group than in the control group. Total and basal tear secretions were significantly lower (P < 0.001) in the diabetic group when compared to control group. The present study indicates that in patients with Type II diabetes, there is a decreased corneal sensitivity, decreased tear stability and secretion, suggesting an ocular surface disease. Early examination of the diabetic patients for the detection of the ocular surface disorders is indicated
Highlights
Non-insulin Dependent Diabetes Mellitus (NIDDM) or Type 2 diabetes constitutes, nearly 95-97% of all diabetic patients in most population groups
We investigated the changes of tear film and ocular surface in diabetic patients by assessing the corneal sensitivity test, tear secretion test and comparing the results with those in a normal control group
Dogru et al18reported that corneal sensitivity was significantly lower in diabetes with poor metabolic control and peripheral neuropathy, but it was not related to the duration of diabetes or the stage of retinopathy
Summary
Non-insulin Dependent Diabetes Mellitus (NIDDM) or Type 2 diabetes constitutes, nearly 95-97% of all diabetic patients in most population groups. Several studies have documented tear secretion and tear film function in non insulin dependent diabetes mellitus, there have been few studies from south Indian population In addition to this there has been a lack of research related to the changes of ocular surface in diabetic patients to clinical parameters of diabetes in south Indian population. We investigated the changes of tear film and ocular surface in diabetic patients by assessing the corneal sensitivity test, tear secretion test and comparing the results with those in a normal control group. Materials and Methods The study included 100 eyes of fifty patients of Type 2 Diabetes Mellitus (Cases) and 100 eyes of fifty healthy individual (Controls) attending the OPD of Department of Ophthalmology, KMC, Hospital Attavar, Mangalore.
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