Abstract
P O S T E R S E S S IO N S intake in control rats to a greater extent than that observed in exercised ones, whereas inhibitors of AMPK had the opposite effect. Exercise was associated with both reduced phosphorylation of the AMPK/ACC signaling pathway and increased phosphorylation of proteins involved in mTOR signal transduction in the hypothalamus.Treatment with leptin reduced food intake in exercised rats that were pretreated with vehicle, although no increase in sensitivity to leptin-induced anorexia after pretreatment with anti-IL6 antibody, AICAR or Rapamycin was detected. Conclusion: Thus, improved responses of AMPK and mTOR to leptin may contribute to the appetite suppressive actions of exercise.
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