Abstract
ABSTRACTObjectives:To compare the sealing ability and biocompatibility of Biodentine with mineral trioxide aggregate (MTA) when used as root-end filling materials.Methodology:The Cell Counting Kit-8 (CCK-8) assay was used to compare the cytotoxicity of MTA and Biodentine. Twenty-one extracted teeth with a single canal were immersed in an acidic silver nitrate solution after root-end filling. Then, the volume and depth of silver nitrate that infiltrated the apical portion of the teeth were analyzed using micro-computed tomography (micro-CT). Seventy-two roots from 3 female beagle dogs were randomly distributed into 3 groups and apical surgery was performed. After six months, the volume of the bone defect surrounding these roots was analyzed using micro-CT.Results:Based on the results of the CCK-8 assay, MTA and Biodentine did not show statistically significant differences in cytotoxicity (P>0.05). The volume and the depth of the infiltrated nitrate solution were greater in the MTA group than in the Biodentine group (P<0.05). The volume of the bone defect was larger in the MTA group than in the Biodentine group. However, the difference was not significant (P>0.05). The volumes of the bone defects in the MTA and Biodentine groups were smaller than the group without any filling materials (P<0.05).Conclusions:MTA and Biodentine exhibited comparable cellular biocompatibility. Biodentine showed a superior sealing ability to MTA in root-end filling. Both Biodentine and MTA promoted periradicular bone healing in beagle dog periradicular surgery models.
Highlights
Root canal treatment is generally performed to treat dental pulp and periapical disease
At 24 hours, a lower relative growth rate (RGR) was observed for Periodontal ligament cells (PDLCs) in the mineral trioxide aggregate (MTA) group than in the negative control group (NC) (P0.05)
After 48 hours, the RGR of PDLCs in both the MTA and Biodentine groups was lower than the NC group (P0.05)
Summary
Root canal treatment is generally performed to treat dental pulp and periapical disease. When the root canal treatment and retreatment fail, periradicular surgery is the last hope for the affected teeth.. The aim of periradicular surgery is not to remove infected apical tissue or the root tip, but most importantly is to reseal the root canal system.. The aim of periradicular surgery is not to remove infected apical tissue or the root tip, but most importantly is to reseal the root canal system.2 For this purpose, a root-end filling material must be applied to fill the root-end cavity and seal the exposed dentine during periradicular surgery. A root-end filling material must be applied to fill the root-end cavity and seal the exposed dentine during periradicular surgery This material must possess sealing ability and biocompatibility. It should have antibacterial qualities and be easy to manipulate.
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