Abstract
7‐11 November 2010, Tenth International Congress on Drug Therapy in HIV Infection, Glasgow, UK
Highlights
The FDA TLOVR algorithm has been commonly used to assess virologic response to antiretroviral (ARV) regimens
A comparison of the FDA TLOVR and FDA Snapshot algorithms based on studies evaluating once-daily vs. twice daily lopinavir/ritonavir (LPV/r) regimens
Multiple studies determined that efficacy of LPV/r dosed once-daily (QD) + nucleoside reverse transcriptase inhibitors (NRTIs) was statistically similar to LPV/r dosed twice-daily (BID) + NRTIs using the FDA TLOVR algorithm
Summary
A comparison of the FDA TLOVR and FDA Snapshot algorithms based on studies evaluating once-daily vs. twice daily lopinavir/ritonavir (LPV/r) regimens. From Tenth International Congress on Drug Therapy in HIV Infection Glasgow, UK. Purpose The FDA TLOVR algorithm has been commonly used to assess virologic response to antiretroviral (ARV) regimens. The FDA Snapshot algorithm has been proposed to replace the TLOVR algorithm, as it is simpler and is expected to yield similar results. Multiple studies determined that efficacy of LPV/r dosed once-daily (QD) + nucleoside reverse transcriptase inhibitors (NRTIs) was statistically similar to LPV/r dosed twice-daily (BID) + NRTIs using the FDA TLOVR algorithm. The purpose of the analyses presented here is to compare the TLOVR and Snapshot algorithms in the context of studies evaluating QD vs BID LPV/r-based regimens
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