Abstract
The anti-inflammatory agents, diclofenac, flurbiprofen and indomethacin, were examined to determine their inhibitory effect on the breakdown of the blood-aqueous barrier in rabbit eyes, following paracentesis. In treated eyes, compared to the non-treated eyes, the increase in protein and fluorescein in the secondary aqueous was inhibited in a dose-dependent manner. Dose-response curves for the non-steroidal compounds were comparable and were in the range of 3×10 −6 –10 −2 m . However, indomethacin did not completely inhibit the breakdown of the aqueous barrier. The observed effects were strongly dependent of the pH of the vehicle and partly correlated with lipid solubility of the agents.
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