Abstract
The effects of 1% CO on cerebral biogenic amine metabolism was studied by measurement of cerebral hemisphere contents of 5-hydroxytryptophan (5-HTP), 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), dihydroxyphenylalanine (DOPA) and dopamine (DA). The results indicated that 1% CO is associated with an increased cerebral hemisphere content of DA. In CO-exposed animals treated with the decar☐ylase inhibitor, 3-hydroxybenzyl hydrazine, the rate of tryptophan hydroxylation was reduced. When the duration of exposure to a given range of arterial oxygen content was matched to that of a group exposed to a low-oxygen gas mixture (5% O 2) the rates of tryptophan hydroxylation were equivalent. This suggests that at a given arterial total oxygen content the tissue oxygen tension and supply are equivalent in low O 2 or CO hypoxia. Assessment of the effects of 1% CO on tyrosine hydroxylation indicated no significant effect on this enzyme step.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
