Abstract
Concentrations of cerebral biogenic amines and their catabolites, and of plasma corticosterone were determined 10 minutes after training and testing of passive avoidance behaviour in mice. Training, and testing of mice that had acquired the task well resulted in statistically significant increases of plasma corticosterone, and of the DOPAC:DA ratio (an index of dopamine (DA) metabolism) in prefrontal cortex, and of MHPG:NE ratios (an index of norepinephrine (NE) metabolism) in hypothalamus and brain stem. There were also decreases of NE in hypothalamus and brain stem, and an increase of 5-HIAA:5-HT (an index of serotonin (5-HT) metabolism) and of tryptophan in brain stem. Some of these changes also occurred in mice merely exposed to the apparatus but not trained. Plasma corticosterone was significantly greater in mice that performed the task well compared to those that did not, and there were significant correlations between this measure and the avoidance performance. Although there was only one statistically significant correlation between a cerebral metabolite and the Avoidance performance (a decrease in hypothalamic NE), there were indications of relationships between cerebral biogenic amine metabolism and the performance.
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