Abstract
Choline-derived trimethylamine (TMA) is a ubiquitous chemical found in aquatic and terrestrial organisms. The oxygenation of TMA to TMA N-oxide has been shown to be catalyzed by one or more forms of the enzyme flavin-containing monooxygenase (FMO) (EC 1.4.13.8). TMA N-oxide appears to play an important role in osmoregulation especially in aquatic organisms. Although once thought to occur only in ‘higher’ vertebrates, FMO activity has been observed in numerous marine invertebrates as well as fishes and has been shown to oxygenate various anthropogenic xenobiotics. It is postulated that the ‘original function’ of FMO may have been that of osmoregulation and then subsequently became an enzyme responsible for the detoxification of xenobiotics.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
