Abstract
1. Introduction It was shown previously that newly synthesized DNA-like RNA (“D-RNA”) is liberated from chroma- tin associated with globular protein particles desig- nated informofers i.e. in the form of specific ribo- nucleoprotein (RNP) complexes [ 1, 21. In the cyto- plasm, m-RNA occurs in two forms: as free m-RNA designated informosomes [3, 41 or as m-RNP asso- ciated with polysomes [ 5, 61. It was shown that a portion of the D-RNA com- plexed with protein in nuclear ribonucleoprotein particles is transferred into cytoplasm and corre- sponds to true mRNA [7-91. However, it is not known whether the informofers as a protein unit are engaged in the transport of mRNA through the nuclear membrane. The direct answer to this ques- tion may be obtained by comparing the proteins of nuclear and cytoplasmic RNP particles. It was found [2, IO] that the nuclear RNP particles contain only one main protein component with a molecular weight of approximately 40,000. Each informofer contains a number of such apparently identical subunits; they have been shown to be an integral part of the nuclear *To
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