Abstract
Selection and mutation are the main forces that shape the codon usage patterns of viruses. Bacteriophages, just like all other viruses depend on their host's translational machinery for replication. The rate of spontaneous C→T mutations is about 100-fold higher in single stranded DNA (ssDNA) than in double stranded DNA (dsDNA). We investigated the synonymous codon usage patterns of ssDNA phages and dsDNA phages to check if the two kinds of phages exhibit any difference in codon usage adaptation. We carried out relative synonymous codon usage (RSCU) analysis of 462 dsDNA phage and 41 ssDNA phage genomes with their respective bacterial hosts. Correlation in RSCU is significantly higher between dsDNA phages and their hosts than that between ssDNA phages and their hosts (p
Published Version
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