Abstract
The aim of the study was to compare the analgesic activities of ethanolic extract of fruits and whole plant of Fragaria vesca in experimental animal models. The extracts were prepared by percolation method and oral toxicity testing was performed as per OECD guidelines. Analgesic activity was assessed by tail flick method (for central action) and acetic acid-induced writhing test (for peripheral action). Fruit extract, whole plant extract and aspirin showed significant analgesic activity, both central and peripheral, as compared to control (p<0.01). Although fruit extract at dose of 500 mg/kg showed better activity than 250 mg/kg (p<0.05). Analgesic activities of fruit extract 250 mg/kg and whole plant extract 500 mg/kg were almost equivalent while aspirin was most potent among all with significantly greater activities as compared to all the extracts (p<0.05).
Highlights
Pain is an unpleasant sensation no doubt, but on the whole it is usually beneficial to man
The above study showed that the ethanolic extracts of fruits and whole plant of F. vesca and standard drug aspirin showed significant central and peripheral analgesic activities when compared to control (p
The central analgesic activity of fruit extract at 500 mg/kg was significantly more than fruit extract at 250 mg/kg and whole plant extract at 500 mg/kg (p
Summary
Pain is an unpleasant sensation no doubt, but on the whole it is usually beneficial to man (or animal). Pain is mainly a protective mechanism for the body. It occurs whenever any tissues are being damaged, and it causes the individual to react to remove the pain stimulus (Guyton and Hall, 2006). Fragaria vesca is a cousin of the wild strawberry. It is found in woods and grasslands in Europe, Western Asia, North America, and temperate areas in Chile. The berries, leaves, and roots of F. vesca have all been used medicinally in the past. The root was once a popular household remedy for diarrhea and the stalks for wounds. One can make a tea with the leaves for diarrhea, digestive upsets, and to stimulate the appetite (Alpine strawberry, 2008)
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