A Comparative Review of Demographics, Incidence, and Epidemiology of Histologically Confirmed Intracranial Tumors in Brazil and Bulgaria.

George S Stoyanov,Boyko K Matev,Yavor Enchev,Peter Ghenev,Fernando Adami,Deyan L Dzhenkov,Anton B Tonchev,Martina Kitanova,Jonathan S Sarraf,Bogomil Iliev,Luis Eduardo W De Carvalho

doi:10.7759/cureus.2203

George S Stoyanov, Boyko K Matev + Show 9 more

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https://doi.org/10.7759/cureus.2203

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Journal: Cureus	Publication Date: Feb 19, 2018
Citations: 2	License type: cc-by

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Intracranial tumors (ICTs) attract numerous scientific teams and tremendous financial resources worldwide. These lesions of the central nervous system (CNS) can be both benign and malignant in biological behavior as well as local or metastatic in origin. We compared data from two studies on primary and metastatic ICTs from Brazil and Bulgaria, based on histopathologically confirmed ICTs from tertiary health centers. Primary ICTs significantly outweigh the frequency of metastatic ICTs. Primary ICTs represent 86.45% in Brazil and 69.17% in Bulgaria, with around 60% of their totals being malignant. There is a statistical dominance of tumors from the neuroepithelial origin, with the most common entry being glioblastoma multiforme. The second-most common primary ICT group comprises tumors of meningeal origin. Metastatic ICTs show great variance; 13.55% in Brazil and 31.38% in Bulgaria of all ICT cases being attributed to them. However, metastatic ICTs are even a more diverse group than neuroepithelial tumors, with the majority of this group comprising metastatic colorectal adenocarcinoma (almost exclusively in males), metastatic breast adenocarcinoma in females, metastatic pulmonary carcinomas (primarily from the non-small cell group with a male predominance), and metastatic melanoma with an even gender ratio.

Highlights

BackgroundNowadays the scientific research of intracranial tumors (ICTs) attracts numerous scientific teams and tremendous financial resources worldwide [1,2,3]
Primary Intracranial tumors (ICTs) significantly outweigh the frequency of metastatic ICTs
The standard has been that studies of primary central nervous system (CNS) tumors must always apply to pathological criteria, while metastatic ICTs may only adhere to the radiological findings [2032]

Summary

Introduction

Nowadays the scientific research of intracranial tumors (ICTs) attracts numerous scientific teams and tremendous financial resources worldwide [1,2,3]. Primary ICTs represent 86.45% in Brazil and 69.17% in Bulgaria of all ICTs, based on the histological verification criteria, with around 60% their total being malignant in nature (Figure 1) Both studies found a statistical dominance of tumors from the neuroepithelial origin, with the most common entries being glioblastoma multiforme, with other astrocytic and glial tumors accommodating for a relatively small number of cases [33,34]. Despite the similarities of the histological findings, there are some visible differences in the results; in Brazil, the most affected age group is 40-59 years, followed by 0-19 years, whilst in Bulgaria, the most affected age group is 40-59 years, followed by >60 years (Table 1) These differences may be attributed to the significantly higher number of metastatic ICTs in the Bulgarian population when compared to the Brazilian population. One of the most intriguing parts of the comparison of results is the wide similarity of the results, despite the significant ethnic differences of the populations, questioning the impact of ethnic factors in CNS tumors pathobiology as described in previous studies [41,42]

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30. McNeill KA