Abstract
Ear mange is an annoying problem for all animal breeders including rabbit's breeders. This study aimed to compare the efficacy of moxidectin and 10% propolis ointment on rabbits infested with Psoroptes cuniculi with especial reference to some related biochemical parameters diagnostic and prognostic value. For this purpose, a total of thirty-two rabbits: 8 non-infested rabbits (control group (CG) and 24 naturally infested rabbits were used. Infested rabbits were equally divided into three groups: 1st group remained without treatment (diseased group (DG)), 2nd group was treated with moxidectin ((0.2 mg/kg body weight) S/C (MG)). Propolis ointment (10%) was applied topically to rabbits of the 3rd group (PG) once daily. Ear scrapes and blood samples were taken on 0, 7, 14 and 21 days. The ear scraping was examined microscopically and the biochemical parameters were estimated and statistically analyzed. The results cleared that moxidectin achieved the complete healing (14th day) faster than propolis ointment (21st day), but MG suffered from a significant (P<0.05) hypoalbuminemia, increased liver and kidney function tests and cortisol levels when compared to PG. Liver and kidney function tests and cortisol yielded good values of the area under the curve, sensitivity%, specificity%, likelihood ratio, PPV%, NPV%, accuracy rate% in DG, MG (except creatinine) and PG. The study concluded that propolis had a prominent antipsoroptic effect without inducing hepatic or renal toxicity. Liver and kidney function tests and cortisol may be useful markers for rabbit mange diagnosis and prognosis and following up its treatment.
Highlights
Psoroptes cuniculi is the main cause of rabbit's ear mange
This study aimed to compare the efficacy of moxidectin and 10% propolis ointment on rabbits infested with Psoroptes cuniculi with especial reference to some related biochemical parameters diagnostic and prognostic value
Infested rabbits were divided into three groups: 1st group remained without treatment (diseased group (DG)), 2nd group was treated with moxidectin ((0.2 mg/kg body weight) S/C (MG))
Summary
Psoroptes cuniculi is the main cause of rabbit's ear mange. It is a worldwide distributed and extensively threats caged rabbits breeding. Propolis means in Greek, entrance to the community this refers to its role in hive defense Another name of propolis is bee glue due to its waxy nature and mechanical properties, bees use it for building or repairing hives and for sealing openings and cracks and smoothing out the internal walls [8]. It was used in medicine by Greek and Roman for its antipyretic, antiseptic and wound healing propriety [9]. It is effective in the treatment of dermatophytosis [11] and sarcoptic mange [6]
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