Abstract
Hart Park virus and rabiesvirus both produce a fatal encephalitis after intracerebral inoeulation into newborn mice. Hart Park murine encephalitis has a more rapid onset than rabies murine encephalitis. By light microscopy Hart Park encephalitis is characterized by a diffuse necrosis of neurons and mild neutrophilie infiltrate, whereas rabies is characterized by many cytoplasmic inclusions (Negri bodies) within neurons and marked parivascular cuffing by mononuclear cells. Electron microscopic examination of infected mouse brain revealed that Hart Park virus and rabiesvirus both “bud” in bullet-shaped particles from cell membranes of neurons and glial cells. However, rabiesvirus, unlike Hart Park, develops in association with retienlo-granular cytoplasmie viral matrices. Because of their morphologic similarities, rabiesvirus and Hart Park virus are included among the newly formed rhabdovirus group.
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