Abstract
The greenness assessment of analytical methods is an important aspect of green analytical chemistry, which focuses on making analytical procedures eco-friendly and safer. This study conducts a thorough comparative analysis of chromatographic methods utilized in the analysis of Cilnidipine (CLN), a commonly employed antihypertensive medication. The research aims to not only evaluate the analytical performance of different chromatographic techniques but also assess their environmental impact, with a focus on promoting sustainable and eco-friendly practices in pharmaceutical analysis.The greenness profiles of twelve chromatographic methods for CLN and its derivatives were evaluated utilizing multiple assessment metrics including the Green Analytical Procedure Index (GAPI), Analytical GREEness (AGREE), Analytical eco-scale (ESA), Chloroform-oriented Toxicity Estimation (ChlorTox scale), Blue Applicability Grade Index (BAGI), and Red-Green-Blue 12 (RBG 12). By quantifying the environmental implications, the study aims to highlight the importance of adopting greener practices in pharmaceutical analysis. This assessment encompasses considerations such as solvent used, energy consumed, and waste generated by the method. The outcomes of this research contribute valuable insights into the selection of environmentally friendly chromatographic methods for CLN, promoting a balance between analytical efficiency and ecological responsibility in the pharmaceutical field.
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