Abstract
An experimental morphological study of the methods of chemodestruction, cryodestruction and laser destruction as those of medical denervation in pharmacoresistant forms of prosopalgia was carried out. The obtained data testify to the presence of evident destructive macro- and microscopic changes both in the nerve trunk and its surrounding tissues when using alcoholic chemodestruction. A lesser degree of morphological changes was observed in phenol chemodestruction. Cryodestruction was characterized by morphological signs of persistent denervation with a minimal manifestation of perifocal changes in the surrounding tissues. The laser method of denervation resulted in replacement of destruction by regeneration in the early period. Perifocal changes were minimal.
Highlights
Pharmacoresistant facial pains belong to the most severe human pain syndromes [1,2,3,4]
Prominent among the above listed ways are puncture methods of chemodestruction used for treating severe forms of trigeminal neuralgia
An aetiological observation over animals from experimental group I showed that their injection was followed by: sluggishness of the animals during all the terms of their follow-up, inhibition of food and behavioural reflexes, formation of massive inflammatory infiltrates in the wound with the subsequent formation of rough connective tissue cicatrices in the perineural tissues, presence of trophic disturbances on the lower extremity with different degrees of their manifestation according to the damaged region
Summary
Pharmacoresistant facial pains (prosopalgias) belong to the most severe human pain syndromes [1,2,3,4]. Recent years have witnessed a tendency for a wide use of mini-invasive technologies for treatment of prosopalgias, including different transcutaneous puncture methods for destructing facial nerve formations. And practically, the following methods of puncture destruction have become the most common ones:. – cryodestruction (cryoneurotomy) of the sensory root and peripheral branches of the trigeminal nerve (Sipitiy V.I., Posokhov M.F., 1984) [10,11,12];. Prominent among the above listed ways are puncture methods of chemodestruction used for treating severe forms of trigeminal neuralgia. The most widespread is the method of alcoholization; it was introduced into clinical practice by Schlősser C. in 1903 and for a long period of time regarded as mini-invasive, technically simple and effective [5,18]. According to findings of the study, conducted by Shengeliya N.Sh. on a high electronic microscopic level, alcoholization develops “the required degree of nerve degeneration, providing a stable disturbance of innervation” [20]
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