A Comparative evaluation of the Efficacay of two oral medication on post operative pain following single visit root canal therapy – An in vivo study

Abstract

AIM : To compare the effects of single dose of two oral medication following single visit root canal therapy in teeth with irreversible pulpitis MATERIALS AND METHODS: 30 patients who reported to KVG dental college sullia, seeking treatment on which single visit RCT was performed . In this double blind study anterior or premolar teeth with irreversible pulpitis without any signs and symptoms of irreversible pulpitis were selected divided into 3 groups randomly. A control group without any medication and two groups receiving a single dose of E-90 and Movon-p respectively immediately after the root canal therapy the intensity of pain was recorded on a 10 point VAS for upto 24hr post operatively. RESULTS :E-90 Etoricoxib-90 (group 1) was found to be clinically significant at 10% more compared to the other two groups in the reduction of post operative pain . (Movon-p) wasmore effective compared to the control group where no medication was given CONCLUSION: A single dose of E-90 considerably reduced thepost operative pain compared to the other I. Introduction Pain is an unpleasant sensation that can significantly interfere with the person's quality of life and general functioning . The prevalence of post operative pain has been reported to be significantly higher associated with single visit than with multiple visit root canal treatment .The prevalence of post operative pain following root canal treatment has been reported to be3-58% . Studies regarding post-obturation pain levels that required analgesics have reported significantly higher prevalence associated with single-visit than with multiple-visit treatment. Non Steroidal Anti-inflammatory drugs (NSAIDS) are the most common analgesics in ambulatory patients. Some drugs can prevent the production of inflammatory mediators involved in producing pain , such as prostaglandins owing to pulpal inflammation and necrosis . NASAIDS are widely available , and they have been reported to be effective in managing endodontic pain . Non narcoticanalgesics ,NSAIDS and acetaminophen can all produce analgesia; therefore , they can be effectivefor managing pulp and periradicular pain . (1) Several double blind , placebo - controlled trials in patients with endodontic pain have been carried out with NASAIDS namely ibuprofen and it has shown good efficacy and safety profiles . Studies have shown that a suitable method for controlling moderate to severe pain is to combine two or more drugs ;Movon -P a combination of aceclofenac and paracetamolAceclofenac is a phenylacetic acid derivative that inhibits synthesis of the inflammatory cytokines interleukin-1b and tumour necrosis factor, inhibits prostaglandin E2 production. Paracetamol has analgesic and antipyretic action with weak anti-inflammatory activity. It produces analgesia by increasing pain threshold and antipyresis by acting on the hypothalamic heat-regulating centre. E-(90) Etoricoxib selectively inhibits isoform 2 ofcyclo-oxigenase enzyme (COX-2).(2) This reduces the generation of prostaglandins (PGs) from arachidonic acid. Among the different functions exerted by PGs, their role in the inflammation cascade should be highlighted. Since no studies have been done using this two oral medication hence the purpose of the study is to compare effects of single dose of two oral medication following single visit root canal therapy in teeth with irreversible pulpitis.