Abstract
A comparative endocrinological and pharmacological view of the maint enance or interruption of pregnancy is presented. Maintenance of pregna ncy, abortive effects, estrogens, androgens, progestagens, and prostagla ndins are considered individually by means of examples to show the effect of hormones on pregnancy. A constant problem in reproductive bio logy is the special behavior in each species. For example, even very sm all doses of estrogen induce abortion in the rabbit, whereas human pregn ancies tolerate extremely large doses of estrogens. It is suggested that teratological investigations be carried out on the basis of a clearly formulated problem using experimental procedures suited to the biological characteristics of the test substances and of the animals.
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