Abstract
Kupilu (Strychnos nux- vomica Linn), is one of the widely used drug in the category of Upavisha. Vishamushti vati is one of the preparation in which Kuiplu is the main ingredient. Kupilu shows toxic symptoms, if it is consumed without proper Shodhana procedures. Strychnine is one of the main chemical constituent available in the Kupilu by which the chemical action of Kupilu is expected. So it is very much essential to study the concentration of Strychnine in raw, Shodhitha kupilu and Vishamushti vati by means of physico-chemical analysis. Physico chemical analysis reveals increased value in loss on drying, total ash, water soluble ash, alcohol soluble extraction, water soluble extraction in Vishamushti Vati and increased value in acid insoluble ash in Ashodhitha kupilu. It is observed that Shodhitha Kupilu was less acidic than other two samples. Strychnine percentage in Ashodhitha Kupilu was 0.44, Shodhitha Kupilu was 0.14 and that of Vishamushti vati was 0.17. Hence it is proved that Shodhitha Kupilu and Vishamushti vati are having less Strychnine percentage compare to Ashodhitha Kupilu.
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