Abstract
30Jun 2016 A COMPARATIVE ANALYSIS OF SERUM MALONDIALDEHYDE LEVELS AS A MARKER OF OXIDATIVE STRESS IN ACUTE MYOCARDIAL INFARCTION CASES WITH AND WITHOUT T2DM. M.A.Raheem , M.Siraj , Rajashekar Reddy , Syed Azhar Ali , Priyanka T N and M Ishaq. 1. Department of Medicine, Princess Esra Hospital (PEH), Deccan College of Medical Sciences (DCMS), Hyderabad, India. 2. Department of Cardiology, Princess Esra Hospital, DCMS, Hyderabad, India. 3. Prof and HOD, Salar-E-millat Research Centre for Cellular and Molecular Medicine, PEH, DCMS, Hyderabad, India.
Highlights
Enhanced oxidative stress resulting due to elevated levels of free radicals in plasma is considered as a mechanism responsible for cardiovascular manifestations in Type 2 diabetics’ mellitus (T2DM)[1]
The reactive oxygen free radicals interact with plasma proteins like LDL and the oxidized LDL formed is involved in foam cell formation resulting in the initiation of atherosclerosis which is commonly associated with the risk of myocardial infarction. [2, 3]
Even in non-diabetic subjects may lead to insulin resistance[4]. the objective of the present study was to carry-out a comparative evaluation of serum MDA levels as a marker of oxidative stress in Acute myocardial Infarction (AMI) patients with T2DM and those without T2DM
Summary
Enhanced oxidative stress resulting due to elevated levels of free radicals in plasma is considered as a mechanism responsible for cardiovascular manifestations in Type 2 diabetics’ mellitus (T2DM)[1]. Even in non-diabetic subjects may lead to insulin resistance[4]. the objective of the present study was to carry-out a comparative evaluation of serum MDA levels as a marker of oxidative stress in AMI patients with T2DM and those without T2DM. 46.47% (14 out 30) AMI cases without T2DM belonged to the over-weight group (BMI 25-29.99).
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