A combination of LMO2 negative and CD38 positive is useful for the diagnosis of Burkitt lymphoma

Yifei Liu,Xiaoge Zhou,Jianlan Xie,Jianguo Zhang,Yanlin Zhang,Yuanyuan Zheng,Tingting Bian

doi:10.1186/s13000-019-0876-3

Abstract

BackgroundTo evaluate the clinical utility of LIM Domain Only 2 (LMO2) negative and CD38 positive in diagnosis of Burkitt lymphoma (BL).MethodsLMO2 and CD38 expression determined by immunohistochemistry in 75 BL, 12 High-grade B-cell lymphoma, NOS (HGBL,NOS) and 3 Burkitt-like lymphomas with the 11q aberration.ResultsThe sensitivity and specificity of LMO2 negative for detecting BL were 98.67 and 100%, respectively; those of CD38 positive were 98.67 and 66.67%, respectively. The sensitivity and specificity of a combination of both for detecting BL were 97.33 and 100%, respectively. In our study, the combined LMO2 negative and CD38 positive results had a higher area under the curve than either LMO2 negative or CD38 positive alone.ConclusionsA combination of LMO2 negative and CD38 positive is useful for the diagnosis of Burkitt lymphoma.

Highlights

To evaluate the clinical utility of LIM Domain Only 2 (LMO2) negative and CD38 positive in diagnosis of Burkitt lymphoma (BL)
We found 74 of the 75 BL cases studied were negative for LMO2 using a cutoff of 30%
We found that LMO2 protein was 100% positively expressed in HGBL; it was only expressed in one of Seventy-five Burkitt lymphomas

Summary

Introduction

To evaluate the clinical utility of LIM Domain Only 2 (LMO2) negative and CD38 positive in diagnosis of Burkitt lymphoma (BL). Results: The sensitivity and specificity of LMO2 negative for detecting BL were 98.67 and 100%, respectively; those of CD38 positive were 98.67 and 66.67%, respectively. The combined LMO2 negative and CD38 positive results had a higher area under the curve than either LMO2 negative or CD38 positive alone. Conclusions: A combination of LMO2 negative and CD38 positive is useful for the diagnosis of Burkitt lymphoma. Burkitt lymphoma (BL) is one of the most studied human malignant tumors that originates in the B cells. It is relatively simple to diagnosis BL in children, it is a challenge to identify reliable subtypes of aggressive B-cell lymphoma in adults [1, 2]. BL has a typical immunophenotype-strong immunoglobulin (Ig) expression and generally expresses markers of B

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Conclusion