Abstract
Diet has a major role in the maintenance of healthy skin, and is a significant factor in the etiology and therapy of certain skin diseases (1). Canine skin diseases are common and some dietary components were shown to improve skin condition and help control disease. These include fatty acids (2), zinc (3), and certain proteins (4). This strategy was incorporated into a therapeutic diet 3 intended to aid the management of canine allergic skin disease, including atopy, flea allergy, and dietary sensitivity (5). Other antiinflammatory and antibacterial components to aid the recovery of skin were included in this diet by the addition of curcumin, aloe vera,vitamin C, and taurine. Curcumin exhibits antitumor, antioxidant, antiviral, immune modulating, and antiallergenic activity (6,7). Aloe vera contains a large number of active components that have recognized antioxidant, antiinflammatory,andantimicrobial properties(8,9).VitaminChas both antioxidant and antiinflammatory activities, and can significantly lower blood histamine in healthy adult humans (10) whereas taurine has known antioxidant properties (11,12). In this study, the potential for a novel combination of aloe vera, curcumin, vitamin C, and taurine to effect the migration of canine fibroblasts and the permeability of keratinocytes to tritiated water was assessed in vitro.
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